Connective tissue and skin are not merely cosmetic; the skin is the human body’s largest immune and protective barrier. Deterioration of the extracellular matrix (ECM) and dermal collagen fragmentation directly fuels systemic low-grade inflammation (inflammaging). High-concentration leukocyte-poor PRP combined with umbilical cord-derived mesenchymal stem cell exosomes stimulates localized microvascular angiogenesis and fibroblast collagen synthesis.
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