Speaking of Rapamycin: it remains the single most robust pharmacological intervention validated by the NIA Interventions Testing Program (ITP), consistently extending mammalian lifespan by 14-23% even when started in late middle age. The clinical debate is dosing architecture: daily dosing causes chronic mTORC2 inhibition, leading to insulin resistance, hyperlipidemia, and mouth ulcers. The consensus among elite biohackers is a strict weekly pulse: 5mg to 6mg taken once every 7 days with grapefruit juice (CYP3A4 inhibitor to boost bioavailability) or high-fat meals. This selectively inhibits mTORC1 to trigger deep autophagy while leaving mTORC2 intact for metabolic stability.
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