If you are banking on somatic organ transplants, you must address the Endothelial Glycocalyx. This microscopic, gel-like polysaccharide layer coats the inside of your 60,000 miles of blood vessels. As we age, systemic oxidative stress and high-glucose spikes strip the glycocalyx bare, leading to capillary rarefaction and organ ischemia. You can drop a 20-year-old cloned heart into your chest, but if the microvascular glycocalyx is destroyed, peripheral tissues will still starve. Supplementing with specialized marine polysaccharides (Sulodexide / rhamnan sulfate) to regenerate the vascular glycocalyx is a mandatory prerequisite for surgical longevity.
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